M4K Team publishes in the Journal of Medicinal Chemistry
In the May and September 2020 issues of the Journal of Medicinal Chemistry, the M4K team and collaborators published two articles on M4K’s open science approach and the chemistry progress to develop the inhibitors for ALK2 as a treatment for Diffuse Intrinsic Pontine Glioma (DIPG).
1. Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma
Deeba Ensan, David Smil, Carlos A. Zepeda-Velázquez, Dimitrios Panagopoulos, Jong Fu Wong, Eleanor P. Williams, Roslin Adamson, Alex N. Bullock, Taira Kiyota, Ahmed Aman, Owen G. Roberts, Aled M. Edwards, Jeff A. O’Meara, Methvin B. Isaac, and Rima Al-awar
2. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma
David Smil, Jong Fu Wong, Eleanor P. Williams, Roslin J. Adamson, Alison Howarth, David A. McLeod, Ahmed Mamai, Soyoung Kim, Brian J. Wilson, Taira Kiyota, Ahmed Aman, Julie Owen, Gennady Poda, Kurumi Y. Horiuchi, Ekaterina Kuznetsova, Haiching Ma, J. Nicole Hamblin, Sue Cramp, Owen G. Roberts, Aled M. Edwards,David Uehling, Rima Al-awar, Alex N. Bullock, Jeff A. O’Meara, and Methvin B. Isaac
Journal of Medicinal Chemistry 2020 63 (17), 10061-10085. DOI: 10.1021/acs.jmedchem.0c01199